The basic principle of Ayurvedic & siddharnmedicine practices was based on the guna of plant parts sap tested on thernproperties of various taste i.e. Sweet, Sour, Salty, Bitter, Pungent andrnastringent. These are the main basic criteria to classify plants for variousrnailments of disease. And this ancient pathy was quite useful without no siderneffect. This successful sustainable pathy frequently used from the ancientrntime. New order of world economy imposed modern medicine pathy which is notrncause based with various side effect, not affordable & not sustainable.rnThere is urgent need for development of sustainable and affordable pathy forrnthe rural poor. The scientific validation of locally available phyto resourcesrnfor recovery of various disease is urgently required. The judicious managementrnfor conservation & cultivation of wild medicinal plants in specific climaternincreases the effective potential of the greater bio-molecules & theirrnsecondary path. Their is urgent need to asses the possibility of fitness ofrnthese bio-molecules with the inside protein of body system. Ecological modelingrnof greater bio-molecules is quite important to enhance the curabilityrnpercentage of the disease.