The present study was carried out to find out the phytochemical screening and antimicrobial activity of different solvent seed extracts of Caesalpinia bonduc. The phytochemical analysis carried out revealed the presence of alkaloids, flavonoids, glycosides, coumarins, saponins, tannins, terpenoids, steroids and quinones in the plants. The antimicrobial activity of three different extracts of Caesalpinia bonduc was evaluate using well diffusion method against Bacillus cereus, Staphylococcus epidermidis, Escherichia coli, Salmonella paratyphi, Beauveria bassiana and Candida albicans. Ethyl acetate extract presence of number of phytochemical than the other solvent extracts. Ethyl acetate extract of Caesalpinia bonduc has least activity against all the tested cultures. The methanol extract of Caesalpinia bonduc showing strong antimicrobial activity against all test species. Our findings showed that Caesalpinia bonduc plant extracts have higher levels of antimicrobial activity.