Antifungal potential of flavonoids and alkaloids from Jatropha curcas and Abrus precatorius was determined against the wilt fungus Fusarium oxysporum. Total 21 extracts were tested at three different concentrations (2.5, 5 and 10 mg/ml) for the mycelia and spore inhibition of the test fungus. All tested extracts were recorded to have significant antifungal potency at 10 mg/ml concentration as all inhibited mycelia and spore germination. Free flavonoids, alkaloids from seeds of J. curcas, bound flavonoids from stem and leaves of A. precatorius showed excellent inhibitory activity against the wilt fungi.