From ancient era, plants have been used as a general source of medicine. From a very long time, Lantana camara is used in traditional medicine system. This plant is used for treatment of various kinds of ulcers, swelling, cataract, itches, eczema and rheumatism. The different parts of the plants (like- leaf, stem, root, etc.) are used in the treatment of headache, eye infection, cough, cold, asthma and hypertension. Lantana camara is scientifically valuable for various therapeutic activity as antipyretic, antimicrobial, anti-inflammatory, antibacterial, antioxidant, wound healing and antidiabetic activity. This review gives us a bird’s eye view on detailed information of this plants and of its various activities along with targeted antidiabetic activity study.