Spices like Zingiber officinale, Rosc.; (ginger) and Trigonella foenum-graecum, L.; (fenugreek) are indispensable for the preparation of our daily food and are reported to possess phytochemicals, which have varied beneficial biological effects. This study evaluates the comparative analysis of phytochemical screening and antibacterial activity of ginger and fenugreek. Ethanol and methanol are the two solvents used for making the extracts from both spices. The comparative analysis of phytochemical screening revealed the presence of carbohydrates, alkaloids, flavonoids, saponins, terpenoids and cardiac glycosides. On comparing the presence of phytochemicals in both solvent extracts, methanol showed the presence of more phytochemicals than ethanolic extract. Antibacterial activity of Zingiber officinale, Rosc.; and Trigonella foenum-graecum, L.; against two common pathogenic bacteria such as Escherichia coli and Staphylococcus aureus was carried out. Both the spices showed antibacterial activity in which Zingiber officinale, Rosc.; has the largest inhibition zone. The present study reveals the quality of Zingiber officinale, Rosc.; and Trigonella foenum-graecum, L.; as a raw material for drug manufacturing and an inevitable nutrient diet in our daily food.