The field experiment was conducted to study the effect of irrigation water quality and the interactions on the content of the active materials for Rocket plant (Eruca sativa Mill) in Karbala province, Touirij district, Al-Hindiya horticulture station, Ministry of Agriculture during the autumn season of 2017 where the experiment included 54 experimental units with two factors: The first factor is the quality of irrigation water (WQ, fresh water, drainage water). The second factor was the following combinations: The control treatment T1, Traditional compound fertilizer (0.6 g.m^-2) T2, nano-compound fertilizer (1 g.L^-1m^-2) T3, Poultry Wastes (300 g.m^-2) T4, Salicylic acid (10 ml.L^-1.m^-2) T5, Poultry Wastes + Salicylic acid T6, nano-compound fertilizer + Salicylic acid T7, nano-compound fertilizer + Poultry Wastes T8, nano-compound fertilizer + Poultry Wastes + Salicylic acid T9), where the experiment was applied according to split-plot design, with three replicates. The results showed that the increase in salinity of irrigation water led to lower the traits of vegetative growth (chlorophyll, the fresh yield for the first cutting, the dry yield for the first cutting, the fresh yield for the second cutting, the dry yield for the second cutting, leaf area and NPK in leaves) and increasing the leaves content of Na. The T3 treatment achieved an increase in the traits of vegetative growth (the fresh yield for the second cutting, the dry yield for the second cutting, leaf area) while the T3 treatment led to increase the leaves content of chlorophyll. The T9 treatment led to an increase of (the fresh yield for the first cutting, the dry yield for the first cutting and NPK in leaves) compared to the control treatment.