Osteoarthritis, a major public health problem, is increasing in prevalence worldwide. This research attempted to encompass valuable knowledge on using main herbs in treatment of osteoarthritis in Traditional Vietnamese Medicine. As a result, we reported 42 species which can be used as alternative therapies and among of them, 32 species used via oral administration and 10 species via external use. Summaries of their pharmacological properties are discussed. As future perspectives, the authors of this work encourage new studies on efficacy and practical application of herbs in treatment of osteoarthritis being future trends and hope that these results may shed light on insight science information of anti- osteoarthritis herbal resources for who are interested in the related field of the anti-osteoarthritis drug development from herbal medicines.