Among beneficial forces, honey bees are the excellent pollinators that can enhance the yield of a crop up to 50%. Cross-pollinated crops are also dependent on this insect. Multiple factors are responsible in reducing the honey bee populations. Fuel odor, volatile chemicals and by products like nitric oxide, nitrogen dioxide gases are lethal not only to bee’s body but also affect the foraging in bees. Memory impairment, disorientation, behavioral dilemma and somatic abnormalities observed when bees forage on neonicotinoids and unhygienic flora. Predators and parasites like bee-eater birds, hexapods like hornet wasps, predatory ants, and beetles, Latrodectus genus spiders and mites of Tarsonemidae family threatening bees especially Acarapis woodi is a serious pest reported from 20th Century. To highlight some threats in short it was reviewed under different aspects leading it towards extinction. So there is need to protect these natural pollinators from pollutants using eco-friendly agricultural practices to harvest their products.