In the present study, the phytochemical constituents and antioxidant activity of various extracts from bark and leaves of Poeciloneuron indicum Bedd. were investigated by different in-vitro methods. Phytochemical studies have confirmed the presence of tannins, alkaloids, terpenoids and flavanoids in almost all the aqueous and ethanolic extracts of bark and leaves. The total estimate of phenolic compounds, flavonoids and free radical assays were performed. The phenolic compounds differed from 0.62±0.23 to 47.70±1.80 mg GAE/g in various solvent extracts tested. Ethanol bark extract of the plant species showed potent antioxidant activity with percent scavenging of 96.07%. The maximum amount of reducing ability using reducing power assay was observed in ethanol and aqueous bark extract (5.01±0.21 OD and 5.00±0.05 OD). Aqueous leaf extract (4.01±0.20 OD) also showed similar results in OD at 700nm for reducing power assay.