Human salivary host derived matrix metalloproteinases (MMPs) are involved in dentin caries pathogenesis. Previous studies suggest that by the inhibition of those MMPs, we can control the dental carries progression. To study the inhibition of human salivary proteinases by bark methanolic extracts of C. fistula and M. indica, we used the gelatin as substrate incorporated with polyacrylamide gel. The total phenolics were determined by Folin-ciocalteau assay and C. fistula bark was found to have more phenolic content than M. indica bark. The inhibition of human salivary proteinases was observed by the treatment of bark extracts of C. fistula and M. indica at 100µg/ml phenolics concentration. Bark extract of C. fistula and M. indica may be used for prevention of dental caries progression.