In the present study, we aimed to assess the effects of exogenous silica (extracted from rice straw) on the biochemical responses in wheat under salt stress (0 and 100 mM NaCl). Results showed that silica significantly alleviated the harmful effects of salinity on plants biochemical activities. Silica application under saline conditions increased JA production which induces signal molecules. These signals molecules initiate signal transduction to activate the defense system. This defense system is represented in the activation of the enzymatic and the non-enzymatic antioxidants. These antioxidants protect silica treated plants from the toxic effect of the reactive oxygen species. This protection appeared in the reduction of the lipid peroxidation and maintained the plasma membrane stability. This active metabolic status was ensured with the sharp decrease in shikimic acid in silica treated plants. Therefore treated plants can withstand the salinity, while non-treated plants could not withstand against salt stress.