Early blight of tomato caused by Alternaria solani is most destructive disease in Pakistan and worldwide. Use of microbial antagonists like Entomopathogenic fungi currently gaining interest to manage Phytopathogens as suitable alternative of synthetic chemicals. In present study, pathogenicity of A. solani was performed by using five different isolates and two Entomopathogenic fungi B. bassiana and P. lilacinus (known as Purpureocillium lilacinum) were evaluated against early blight pathogen. Results showed that isolate 1 showed highest disease severity of early blight followed by isolate 4, isolate 2, isolate 3 and isolate 5 respectively. Both Entomopathogenic fungi inhibited the mycelial growth of A. solani under dual culture, volatile and non-volatile metabolites assays. P. lilacinus showed highest pathogen growth inhibition as compared to B. bassiana in all assays. Non-volatile metabolites showed higher antifungal ability as compared to volatile metabolites. To our knowledge present study is first report which described the antifungal potential of P. lilacinus against plant pathogen.