Boerhaavia diffusa is one of the renowned medicinal plants used to treat large number of human ailments. The Plant in whole or its peculiar parts (Aerial parts and Roots) have a numerous medicinal properties and are used by endemic and other people in India and various phytochemical, pharmacological, experimental and clinical investigations are done by many scientist, researchers etc. To clearly understand the ancient Ayurvedic, endemic and tribal usage. This paper includes the evidence-based overview of pharmacological and phytochemical properties of the aerial parts and the roots of Boerhaavia diffusa, which may be helpful to establish a standard natural drug for further research.