Parthenium is an invasive weed which causes severe yield losses in different crops. Weed-crop competition is main factor. For better crop production, weed control beyond the thre should density level is key component of integrated weed management strategy. Use of synthetic herbicides is key component of weed management and is considered the most effective, time saving and economical way to control targeted weeds. The present review highlights the chemical management of most important weed Parthenium.