Plant extracts play a major role in influencing the synthesis of metal oxide nanoparticles. Cerium oxide nanoparticles (CeO₂-NPs) have demonstrated promising methodologies as remedial specialists in clinical sciences. The physicochemical properties of CeO₂-NPs such as size, surface charge and agglomeration status in fluid assumes significant jobs in a definitive communication of the NPs with target cells. Recently, CeO₂-NPs have been combined through a few bio-coordinated techniques applying regular and natural lattices to prepare biocompatible CeO₂-NPs by solution combustion synthesis. A liquid concentrate of Tridax procumbens was used as a diminishing expert for the green association of CeO₂-NPs to form TP-CeO₂-NPs. The significance of using the plant extract in the synthesis of TP-CeO₂-NPs was characterized by Powder X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), UV-Visible and Fourier-transform infrared spectroscopy (FTIR) examinations. XRD diffractograms revealed the unadulterated cubic ceria arrangement with fluorite structure having crystallite quantities to the extent of 10 – 50 nm. FESEM analysis showed the penetrable nanostructured materials. UV-Visible range demonstrated trademark osmosis generally outrageous at 342 nm. The sharp tops in the FTIR range confirmed the presence of Ce-O extending mode. The biological characterization revealed the procoagulant property of the TP-CeO₂-NPs. The higher concentration of the TP-CeO₂-NPs evaded the requirement of calcium chloride to coagulate the blood plasma as evidenced in activated partial thromboplastin time (APTT) assay. TP-CeO₂-NPs enhanced the aggregation of platelets and the NPs were devoid of hemolytic property.