Medico-botanical study was conducted during 2018-2019 for the documentation of medicinal trees in Rampur district. A total of 67 angiospermic trees belonging to 57 genera under 35 families were recorded for the first time. More than 45 diseases treated by different parts of trees, such as bark (20%) followed by flowers (19%), fruits (15), seeds (7%), gum, roots and nuts (3%), pods, peel and latex (2%) were recorded respectively. The family Mimosaceae showed maximum representation with 6 species. Acacia catechu (L.f.) Willd., Acacia farnesiana (L.) Willd., Butea monosperma (Lam.) Taub., Erythrina variegata L., Helicteres isora L., Holoptelea integrifolia (Roxb.) Planch, Kigelia africana (Lam.) Benth., Prunus persica (L.) Batsch, Terminalia bellirica (Gaertn.) Roxb., Terminalia chebula Retz. and Thespesia populnea (L.) Sol. ex Corrêa are rare angiospermic trees in Rampur district.