In the present study we investigated the effect of different salinity levels (0, 50, 100, 150 and 200 mM NaCl) on growth and yield of two muskmelon genotypes. Regression analysis showed that salinity stress adversely affected the morphological and physiological attributes of both genotypes. Relatively, genotype ‘T-96’ showed more resistance and gave greater vegetative growth and yield as compared to ‘Bukhara’. In both genotypes, leaf Na⁺ content increased, while K⁺ and K⁺/Na⁺ ratio decreased with the increase of salinity concentrations. Results also exhibited that genotype ‘T-96’ showed better tolerance to salinity stress, possibly due to accumulating maximum K⁺ and least Na⁺ ions, keeping higher photosynthetic rate and stomatal conduction and ensued greater biomass and yield.