Severe Acute Respiratory Syndrome Corona-Virus 2 (SARS-CoV-2) has put the entire globe into unrest. Unavailability of specific drug against the virus is more imperative. This demanding situation requires development of pharmacophores for efficient treatment against severe acute SARS-CoV-2. The crystal structure of SARS-CoV-2 main protease (M^pro) has been released, thus can be used for fast in silico molecular docking. This may result into identification of active bio-molecules chiefly phytochemicals. In silico molecular docking revealed that the phytochemical, luteolin effectively binds to the active pocket of the SARS-CoV-2 main protease.