This present study reveals the effects of orchid buds ethanolic extract on dysentery. Dysentery is a bacterial infection and many kinds of bacteria may create dysentery. In this study one bacteria named as salmonella has taken. Salmonella is a genus of rod-shaped gram -ve bacteria of the family Enterobacteriaceae. Though salmonella poisoning is generally not a severe illness, it can be fatal in certain people and can cause dangerous dehydration phytochemicals of orchid buds were interacted with one enzyme of salmonella i.e. L-Histidinol dehydrogenase. All the phytochemicals of orchid buds were considered as ligands and the L-Histidinol dehydrogenase enzyme was taken as a receptor. All the operation was carried out in Biovia discovery studio under molecular docking menu. It gives the potential phytochemical of the taken plant which can act as a powerful drug against microbes. L (+) Aspartic acid can inhibit the enzyme involved in metabolic pathway of salmonella