Coronavirus disease 2019 (COVID-19) has been increasing and has a widespread prevalence hence it is receiving extensive attention for its incidence. COVID-19 infection is known to affect individuals with weak immunity more severely. Immune functions are requisite for shielding the body against attack by pathogens, and thus play an essential role in the maintenance of health. Therefore, the ingestion of foods with immune-modulating activities is considered an efficient way to prevent immune functions from declining and reduce the risk of infection or cancer. The present review describes Ashwagandha (W. somnifera) immunomodulatory effects, activity against microbes and infection, general health benefits.