The naturally occurring resources like coconut oil, ginger extract, and vitamin E possess substantial beneficial effect on human skin. The phytochemicals of coconut oil and ginger extract have anti-oxidant and anti-microbial activities. In the present work, a value added virgin coconut oil was developed mixing ginger extract and vitamin E with it. The oil was tested for its efficacy against bacteria and fungi that are potent causative agents of skin infection in human beings. The oil described in this article, is rich in anti-oxidants and having anti-aging property. Regular use of this oil may protect the skin from any getting infected by microbes as well as prevent the skin from premature aging. The extraction of coconut oil, ginger and vitamin E from wheat germ was done by super critical fluid extraction in pilot scale, using carbon dioxide as solvent. The molecular docking was done to support the wet lab data of anti-microbial activities of this oil with in-silico analysis.