The Menispermaceae family of flowering plants comprises of about 71 genera and 450 species. Menispermaceae are mostly climbing plants and the majority of species can be found in countries with a tropical climate. The main feature historically used to define the family is the curved seed found in many of the genera, hence the common name moonseed family. The family contains a number of plants with scientifically recognized important pharmacological activities. The aim of this study was to determine the anatomical characteristics of stem, leaf, petiole and trichome morphology of Anamirta cocculus, Cissampelos pariera var. hirsuta and Cyclea peltata. Anatomical features are more conserve therefore useful for taxonomical studies. These characteristics proved to be useful to distinguish the species of taxonomic studies.