Indigenous plants have been attracting attention from the food industry because of their unique appearance, flavor and nutritional value. Syzygium lineatum (DC.) Merr. & L.M. Perry (S. lineatum) is an indigenous plant and has recently been used for processed foods in the Province of Apayao and Lallo, Cagayan. In the Philippines, S. lineatum berry (malibado) is one of the fruits that it is native to Luzon originating from primary forests at low to medium elevation. S. lineatum berries are believed to contain antioxidants. It is also known as an excellent source of Vitamin C, a very good source of dietary fiber, and a good source of the essential dietary mineral and may contain phytonutrients that brings varieties of health benefits. S. lineatum is now rarely found in its natural habitat, a fact that drives the need to implement conservation measures. The best way to do this is to promote its usefulness as a highly nutritious food source which could be provided by data on its functionality as well as the phytochemicals or secondary metabolites it contains. With better appreciation, demand will come leading to its wider propagation in the country. The functionality of S. lineatum leaves and bark extract was evaluated on their biological activities. The results obtained indicated that the crude extract of S. lineatum contain substances with antioxidant property, cytotoxicity property using brine shrimps and substances with anthelmintic property against the worm eggs from the sheep and earthworms. Functionality of S. lineatum could be attributed to the presence of bioactive constituents that can provide health and wellness through its therapeutic and pharmacological benefits.