The increase of the world population and change in climatic conditions lead to the drought and shortages of food will happened in the most countries of the world. In Ethiopia, most of the time affected by drought and this is because about 60% of the country is dryland and in these parts of the country annual rainfall is low and seasonal and inter-¬annual variability is high. Thus, given attention to the drought resistance plant resources will decrease the risks. Cactus is a drought-resistant plant and it has the potential to mitigate the climate, environment and secure the food and feed for humans and animals respectively. Cactus pear which is known as “Beles”/” Quliqualabhri” in Tigray northern Ethiopia, is adapted to drought areas of the region and is used as feed, food, fence, and source of income to secure in both food and nutrient. The objective of this review paper was to show the role of cactus in climate-resilient, food security, energy, and pharmaceutical to achieve goals of the Ethiopian green economy; to declare the challenges in utilization and development of cactus -based Agri-business and to forward its future perspectives endorsements and elucidations. Hence, the cactus pear is strategic and has a potential advantage of carbon sequestration, promoting renewables energy, bio-material development and food, pharmaceutical and cosmetic industries. However, this crucial wild plant is given little attention in research and development, having a lack of postharvest handling technologies and facilities as well as invasion of cochineal pests are serious challenges in the utilization and development of cactus pear. Therefore, it is important to have a postharvest technologies and facilities, high qualified cactus base researchers and professionals and rethinking and looking over the cochineal pest and its damage are best future perspective solutions to achieve goals of Ethiopian green economy and to have an effective reduction of food poverty.