This study aims at documenting different plants possessing medicinal properties which are found in the riparian zone of Chaliyar river in Malabar region of Kerala. Different plants (about 106 nos.) which are used for treating different ailments belonging to 48 families were collected and studied their medicinal properties. Among them Asteraceae members found to be higher in number, followed by Euphorbiaceae, Malvaceae, Fabaceae and Lamiaceae. Most of the plants are used for the preparation of traditional herbal medicines by local inhabitants along kerala.