Aim: To investigate the antibacterial efficiency of aqueous extract of 12 medicinal plants of India against nosocomial pathogens. Method: The aqueous extracts of 12 medicinal plants tested solely and in combination with synthetic antimicrobial drugs against, MDR E. coli, K. pneumomiae, S. aureus, E. aerogenes and Pseudomonas aeruginosa capable of producing vancomycin resistance, β-lactamase carbapenems and Metallo- β-lactamases. Result: As per MIC assay almost all plant extracts able to inhibit the growth of nosocomial MDR pathogens except Azadirachta indica when tested solely in MIC assay. The better MIC recorded (11-50 µg/ml) with the synergistic application of plant extracts with antibiotics thus noted to control MDR pathogens convincingly. Conclusion: The investigation of plant species available in India showcased capabilities to control MDR nosocomial Gram-positive and Gram-negative bacteria. Favourable antibacterial activities displayed by aqueous extract of medicinal plants once tested solely or in combination with synthetic drugs.