Background: Prameha is a Tridoshaj, Kapha predominant disease. Acharya Charak, Sushruta and Vagbhata included it in Ashtamahagada. Madhumeha (Diabetes mellitus) is predominantly a Vatika disease. Due to similarities of sign and symptoms, Madhumeha can be correlated with Diabetes mellitus type II. Prabhutamutrata or avilmutrata are the clinical features of Madhumeha. Aim: To evaluate the effectiveness of Tryushanadi gudika in the management of Prameha with special reference to Diabetes mellitus type II. Material and Methods: 40 subjects (20 in each) will be classified randomly into 2 parallel groups. Group A i.e. Trial group - Tab. Metformin 500 mg will be given before meal two times a day with lukewarm water for 30 days and Group B i.e. Control group – Tryushanadi gudika 500 mg will be given before meal two times a day with lukewarm water for 30 days. Assessement will be noted on 0, 30^th & 60^thday. Result: Variations will be seen in subjective as well as objective parameters and inferences. Conclusion: The effectiveness of Tryushanadi gudika will be more than Tab.Metformin