A field experiment was carried out entitled “Effect of integrated nutrient management on growth and yield performance of lettuce (Lactuca sativa L.)”cv. Iceberg and Lollorosso in central (U.P), in Factorial Randomized Block Design with three replications. The experiment was conducted at the Horticulture Research Farm of the Department of Applied Plant Science (Horticulture), Babasaheb Bhimrao Ambedkar University, Vidya-Vihar, Rae Bareli Road, Lucknow (U.P.), India; during rabi season of 2016- 17. The experiment comprises of different doses of Treatments i.e. N P K (100%) (Control), FYM (100%), Vermicompost (100%), Biofertilizer- ( 100%), FYM +Biofertilizer (50% + 50%), Vermicompost + Biofertilizer (50% + 50%) and N P K + Biofertilizer (50% + 50%). The vegetative growth, yield Performance attributing characters were recorded maximum plant height (24.97 cm), number of leaf ( 37.00 ), length of leaves (21.19cm), leaves width ( 13.98 cm), Plant spreads (East-West ) and (North-South) direction,(44.65cm, 41.09cm) yield characters Root length (10.67cm), Root spreads (10.05cm), Root weight in (65.00g) Yield in (746.67g).Varieties iceberg superior than Lollorosso.