Fruits and vegetables are essential sources of health due to presence of fiber, vitamins and antioxidant compounds in them. Fungi are mainly responsible for spoilage of fruits and vegetables. Many changes occur in composition of antioxidant compounds during post-harvest spoilage. Some fruits and vegetable will be studied, which can be collected from crop land of Gujarat. Poor handling practices and storage are responsible for fungal infection or spoilage. Some technics are there for prevention of post-harvest spoilage control.