The genus Cynoglossum L. consists of 55 species and it is widely distributed all over the world. It belongs to the Boraginceae family; Members of Cynoglossum L. contain mainly pyrrolizidine alkaloids of many types that are reported to be used in various indigenous medicinal systems throughout the world for the treatment of cough, burns, wounds, ear infection, fever, antibacterial and sometimes as veterinary medicines. A wide range of phytochemical compounds like phenolic, tannins, alkaloids, flavonoids are isolated and identified from different species. Some plants of this genus were reported to be used for medicinally for their anti-inflammatory, antihyperglycemic, antihyperlipidaemic, analgesic, diuretic, antifertility, hepatoprotective activity antioxidant activity, etc. The literature on the genus of Cynoglossum L. is not well organized. Therefore, in the present study, a review has been carried out on various detailed pharmacognostic as well as medicinal values of the genus.