Several halophytic Atriplex species have been explored in the past for their possible use in reclamation of salt-affected soils. The aim of this research is to evaluate the phytoremedial potential of Atriplex lindleyi for Cd, Ni, and Zn along with its defense techniques and physio-morphological changes as it can interact, sequester and detoxify heavy metals. The results showed greater accumulation of Ni and Zn in plant tissues as compared to Cd. Defense responses through photosynthetic pigments and proline were also found to be varied in heavy metal treated plants. It was observed that most of the heavy metals absorbed by the plant were retained in the root i.e., 4.97, 29.31, and 597.2 mg kg^-1 in comparison to the metal transported to above-ground parts of the plant i.e., 2.92, 23.25, and 182.74 mg kg^-1 for Cd, Ni and Zn, respectively establishing this plant as a phytostabilizer. In conclusion, Atriplex lindleyi can be recommended as a potential candidate for the phytoremediation of Ni and Zn.