Parthenium hysterophorus L. is considered as one of the harmful weeds because of its invasiveness, rapid multiplication rate and adverse impacts on environment and human health. The novelty of this work is to manage the weeds by employing organic matters instead of harmful chemical weedicides which have an adverse environmental impact due to accumulation in soil and leaching to water bodies. Researchers have studied the allellopathy impact of the plant, however there is little report available on the use of this extract as natural herbicide. This study was carried out to assess the allellopathic effect of the aqueous extract of leaves of Tamarindus indica on the control of noxious weed Parthenium historephorus L. The extracts of the leaves were used in same concentration (00 % - 100%) and their impact on seed germination and growth of seedlings were observed. The results obtained from utilizing Tamarindus indica. extract showed more effective in terms of inhibition of germination, seedling growth, seedling vigour indices and tolerance indices. The experiment also showed complete inhibition in germination of seed. The current study gives an idea about the use of organic products from plants considered as better alternatives to harmful synthetic herbicides which is the eco-friendly way to biocontrol the weeds to reduce environmental pollution.