Asteracantha longifolia and Leucas aspera are ragrded as weeds they grows in swampy, marshy waterlogged and dry, open, sandy soil where there is no human intervention. In this present study, we have performed phytochemical analysis to validate their phytochemical constitution. The obtained results supports us to say that the plants were having therapeutic principles. The purpose of writing this article is to pour limelight on the application part of weeds which are available in the rural premises to cater the unmet health needs of farming communities, for the sustainable maintenance of livelihood in the rural setup as well as the conservation of biological resources.