Biogenic amine comprises of molecules like dopamine, epinephrine and norepinephrine secreted by the adrenal medulla in response to stress and thereby directing the human body to respond to respond to the stress. Biogenic amines have been reported to occur in Portulaca oleracea and Gomphrena globosa These catecholamines are known to induce growth in certain pathogenic species of Escherichia coli. The current study aims to study the effect of catecholamine present in Portulaca oleracea and Gomphrena globosa on the growth of Escherichia coli (wild type) and Lactobacillus sp.