The present paper deals with botanical sold by the vendors in Dhule, Nandurbar, Jalgaon, and Nasik Districts of North Maharashtra (India) ethnobotanical survey was carried out few years and information was obtained through open discussions and interviews with tradipracititioners. Presently, 27 plant species belonging to 27 genera and 21 families are communicated. Of these, 07 species are noted for first time from Indian region, as where 04 species although recorded so useful, but their parts are different These are administered in different forms of recipes e.g.- paste, powder, extract, ash, decoction etc. Even they are used raw or sometimes simply warmed. In many cases, they use them as a sole drug or occasionally supplemented by other botanicals or domestic substances like sugar, cow ghee, honey etc. These are used to combat about 22 human disease such as piles, skin, diarrhoea, deafness, bile, leucorrhoea, urination, respiratory track, diabetes, rheumatism, sexual vigour, enflunza, ring worms, tuberculosis, cancer, malaria, tonsillitis, hepatitis, jaundice, constipation, eczema, tetanus etc. The data include some chemical constituents of plants and accrued is assessed by cross-cultural comparisons with other Indian claims to bring out their veracity and uniqueness of the claims. The objective of investigation was to gather and document information in plants on utilization of botanicals by the tradipractitioners in the region. These drugs, if studied further on scientific lines, may yield valuable lead molecules and serve as additional sources of medicine.