Vaginal infections are so prevalent in women and they represent the main cause to seek medical consultation for adult women. 75-85 % of women in developing countries have ever had a vaginal infection and their symptoms have been associated with anxiety, depression and negative impact on quality of life. Bacterial Vaginosis BV and Vulvovaginal Candidiasis VVC are the two most common forms of vaginal infections in females in developing countries. Ayurvedic herbs have been widely used in treatment of microbial infections and these plant metabolites have been used worldwide for higher therapeutic efficacy and lesser side effects. The extraction and characterization of these metabolites from the natural sources resulted into new drug discovery with better therapeutic effect and acceptability to patients due to lower adverse reactions. This review summarized and focused on those medicinal plants belonging to plant families Alliaceae, Lamiaceae, Myrtaceae, Meliaceae, Poaceae, Ranunculaceae, Geraniaceae, Solanaceae, Apiaceae, Fabeaceae, Berberidaceae, Araliaceae, Cyperaceae, Asteraceae, Grossulariaceae, Melianthaceae, Zygophyllaceae, Ericaceae; used in treatment of bacterial and fungal vaginal infections. The latest researches and their results also summarized here with the description of plant, structures of their active constituents and their related pharmacological effects in inhibiting microbial vaginal infections.