Panduroga is a Rasapradoshaja, pitta pradhana vyadhi which can be correlated with Iron deficiency anemia. It is the commonest nutritional deficiency disorders present throughout the world and its prevalence is higher in developing countries like India. A comparative study conducted to assess the efficacy of Mandoorbhasma and to compare the efficacy of Mandoorbhasma with and without Guduchi Ghana in Pandu. Total 40 patients were divided into two equal groups. Group A patients were given Mandoorbhasma 250mg two times a day and group B patients were treated with Mandoor bhasma 250mg along with Guduchi Ghana 500mg two times a day with water for 30 days. Subjective and Objective parameters were assessed before and after treatment. The significant improvement was observed in both Groups. Group B showed more improvement in all parameters than group A. So it can be concluded that Mandoorbhasma with Guduchi Ghan is effective in the management of Pandu.