Oil palm (Elaeis guineensis Jacq.) Is a mainstay of industrial crops for the Indonesian economy which has survived during a prolonged economic crisis and is one of the plantation commodities that contribute a large foreign exchange to the country. Oil palm cultivation is faced with the presence of plant-disturbing organisms which are a problem. One of the plant-disturbing organisms in oil palm cultivation is the presence of weeds. The presence of weeds can cause many losses, including reducing production, reducing the quality of production, disturbing the work of farmers, etc. This study aims to determine the effectiveness of the Isopropyl Amine Glyphosate herbicide for weed control in oil palm plants. This study aims to determine the effectiveness of the herbicide Isopropyl Amine Glyphosate for weed control in oil palm plants. The research was conducted in Cinta Mekar Village, Serang Panjang District, Subang Regency, West Java Province from December 2019 to March 2020. This experiment used an experimental method with a randomized block design consisting of 7 treatments and 4 replications. The treatments consisted of the herbicide Isopropyl Amine Glyphosate at a dose of 360 g/ha; 480 g/ha; 600 g/ha; 720 g/ha; 840 g/ha; manual weeding; and Control. The results showed that the Isopropyl Amine Glyphosate herbicide dosage 360 - 840 g / ha was an effective herbicide in controlling broadleaf weeds such as Borreria alata and narrow leaf weeds such as Axonopus compressus and Ottochloa nodosa in oil palm cultivation. Herbicide Isopropyl Amine Glyphosate at all doses did not show symptoms of poisoning in immature oil palm plants.