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VOL. 6, ISSUE 3 (2021)
in-vitro protease and hyaluronidase inhibitory activities of Crotalaria pallida seed extracts
Authors
Sumachirayu CK, Kusuma CG, Vinod Gubbiveeranna, Bhavana S, Nagaraju S
Abstract
In the present study, three solvent extracts (ethyl acetate, acetone and methanol) of Crotalaria pallida seeds were prepared and evaluated for antioxidant, protease inhibition and hyaluronidase inhibitory activities. All the three extracts showed significant inhibition among the tested activities. In DPPH assay, methanol extract has showed highest radical scavenging activity with IC50 value of 114 µg/mL in comparison to acetone and ethyl acetate extracts. In TAA, acetone extract has showed highest antioxidant activity with 17 µg/mL (measured in terms of GAE). In FRAP assay, methanol extract has showed significant reduction potential with 113 µg/mL. Further, in hyaluronidase inhibition assay, acetone extract has showed highest inhibition with IC50 value of 443 µg/mL and in protease inhibition assay, methanol extract has showed maximum inhibition with IC50 value of 459 µg/mL.
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Pages:229-234
How to cite this article:
Sumachirayu CK, Kusuma CG, Vinod Gubbiveeranna, Bhavana S, Nagaraju S "<em>in-vitro</em> protease and hyaluronidase inhibitory activities of <em>Crotalaria pallida </em>seed extracts ". International Journal of Botany Studies, Vol 6, Issue 3, 2021, Pages 229-234
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