The medication is solution properties arsenic harming, tonic, diuretic, uterotonic and sterility in ladies and leaves is shown especially in diabetes. Diabetes mellitus is an endocrine, metabolic problem wherein the homeo-balance of sugar and lipid digestion is inappropriately controlled by the pancreatic chemical, insulin, eventually bringing about expanded blood glucose. In our examination, diabetes was initiated in rodents by single intraperito-neal infusion of Streptozotocin (STZ) at a portion of 45mg/kgb.w. The hepatoprotective adequacy of ethanolic concentrate of Costus spicatus (ACS) at a portion of 500 mg/kg b.w. was examined. Diabetes mellitus is related with reformist metabolic insanity, deteriorating glycemic control, and morphological changes in the liver, pancreas and different organs. Compared to the lipid profile in control and experimental rats 167.3±7.* maximum values and minimum values103.6±6.7*.