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VOL. 6, ISSUE 3 (2021)
Evaluation of diuretic activity of ethanolic extract of Stigma maydis in rats
Authors
Nikhlesh Birla, Sumeet Dwivedi
Abstract
Stigma maydis (Zea mays) is yellowish thread-like strand found inside the husks of corn. Corn Stigma measure 4-8 in (10-20 cm) long and are collected for medicinal use before the plant is pollinated. The diuretic activity of ethanolic extract of Stigma maydis in albino rats was studied by the lipschitz Test. The diuresis activity was determined by administered the rats with different dose treatments of 200 mg/kg (low), 400 mg/kg (medium) and 500 mg/kg (high) of ethanolic extract of Stigma maydis. Cumulative urine volume was significantly increased with the dosage levels (200-500 mg/ kg). The urinary excretion of water and electrolytes exhibited by standard drugs were significantly, as compared to control group over a period of 24 hours. After 7 h furosemide treated group showed higher indices for diuresis (4.71), lipschitz value (2.09) and also After 24 hr also Furosemide treated group showed higher indices for diuresis diuresis (3.70), lipschitz value (3.37). Standard drugs showed higher values of saluretic index (Na+ 1.95, k+1.72 Cl- 1.71) and (Na+ 1.46, k+1.16 Cl- 1.26) were observed with different dosage of ethanolic extract of stigma maydis treated groups. the higher natriuretic values were observed with urea treated group (Na+/ K+ 3.23) where as ethanol extract of stigma maydis treated group shown (Na+/ K+ 3.26) moderately good natriuretic effect as compare to standard drug treatments. From the result it can be observed that ethanolic extract of Stigma maydis has shown a significant diuretic activity by increasing urinary output and increased excretion of sodium, potassium, chloride when compared to control.
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Pages:481-484
How to cite this article:
Nikhlesh Birla, Sumeet Dwivedi "Evaluation of diuretic activity of ethanolic extract of <em>Stigma maydis </em>in rats ". International Journal of Botany Studies, Vol 6, Issue 3, 2021, Pages 481-484
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