ARCHIVES
VOL. 6, ISSUE 4 (2021)
In vitro study on anti-diabetic and antioxidant activities of acetone extracts from the leaves of Trichosanthes cucumerina
Authors
E Ponmalar
Abstract
The main objective of this work is to evaluate the in vitro anti diabetic and antioxidant activities of acetone extract from the leaves of Trichosanthes cucumerina. The selected plant extract was studied for their effect on inhibition of glycosylation of haemoglobin, glucose transport across yeast cells, inhibition of alpha amylase, alpha glucosidase, inhibition of lipid peroxidation and metal chelating activity. It was found that the percentage increase of the rate of uptake of glucose into yeast cells was linear in different glucose concentrations used. Acetone extract from the leaves of T. cucumerina showing the maximum increase in 25mM Glucose concentration i.e. 68.79% at 100μg/mL. In diabetes mellitus higher amounts of glycated hemoglobin indicates poor control of blood glucose levels and inhibition of inhibition of alpha amylase 83.64%, alpha glucosidase 69.33%. The results of the work indicate that the acetone extract from the leaves of T. cucumerina possessed considerable in vitro anti diabetic activity and further these effects need to be confirmed using in vivo models for its effective utilization as therapeutic agents.
Download
Pages:546-551
How to cite this article:
E Ponmalar "<em>In vitro</em> study on anti-diabetic and antioxidant activities of acetone extracts from the leaves of <em>Trichosanthes cucumerina </em> ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 546-551
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.