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VOL. 6, ISSUE 4 (2021)
Comparative evaluation of genotoxic suppressant effect of Paederia foetida (L) and Terminalia arjuna (Roxb.) on chromatic aberration induced in Allium Cepa model by capsaicin
Authors
Gogoi J, Alom H, Bora A, Das K
Abstract
Capsaicin is an active component of chili produced by genus Capsicum sp. In spite of the various beneficial effects of capsaicin, it has also been reported with toxic effects in terms of dermatological injury, ophthalmic injury, gastro-intestinal problems and systemic toxicity. On other hand, there are many plant metabolites reported with toxicity suppression activity. So, the present study was designed to evaluate genotoxicity suppressing property of Paederia foetida (PF) and Terminalia arjuna (TA) induced by pure capsaicin and methanolic extract of Capsicum chinense (MCC) in Allium cepa model. Five treatments (Normal, Capsaicin, MCC, PFMCC, TAMCC) were formulated to study the effect. Mitotic index was observed and calculated by using Foldscope. The result showed mitotic index in capsaicin as 14.29 ± 2.22 on day one followed by negligible number of dividing cells. The mitotic index was recorded to be 15.89 ± 2.54 in day one and 18.91 ± 4.13 in day three for TAMCC. In case of PFMCC, 17.91 ± 2.35 in day one and 23.54 ± 2.35 in day three. Thus, it could be concluded that PFMCC showed significant increase in normal dividing cells as compared to TAMCC on third day which surpass toxicity of capsacin. Further studies on PF would help to get an efficient herbal formulation for suppression of genotoxicity of various toxic compounds.
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Pages:445-448
How to cite this article:
Gogoi J, Alom H, Bora A, Das K "Comparative evaluation of genotoxic suppressant effect of <em>Paederia foetida</em> (L) and <em>Terminalia arjuna</em> (Roxb.) on chromatic aberration induced in <em>Allium Cepa</em> model by capsaicin ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 445-448
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