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VOL. 6, ISSUE 4 (2021)
Determination of cytotoxicity of a poly herbal ‘Meta-block 9‘tablet powder and its phytosomes on MCF-7 and MCF-10A cell lines, in-vitro
Authors
Jayni J Maru, Swati S Patil
Abstract
The primary healthcare of majority of population is dependent on natural herbs. The concept of combining different herbs has been highlighted in the ayurvedic literature ‘Sarangdhar samhita’. Phytoconstituents like alkaloids, saponins, tannins, flavonoids alkenyl phenols, terpenoids, sesquiterpene lactones and phorbol esters contribute to the therapeutic effect of the natural herbs. Combination of different herbs with varying potency produces greater therapeutic effectiveness compared to the single herb. Poly herbal combination of drug mainly acts due to synergistic effect of the phytoconstituents present in the individual herbs. Meta-block 9 tablet consists of hydro-alcoholic extracts of herbs like haridra, amla, arjuna, ashwagandha, tulsi, marich, gudduchi, guggulu, and yashtimadhu. These herbs are used in ayurvedic rasayana therapy. Since the active phytoconstituents present in the poly herbal mixture have poly-phenolic multi ring structure and poor lipid, water solubility their absorption in the cell is significantly less. So the tablet mixture is formulated into a novel drug delivery system i.e a Phytosome. Active phytoconstituents present in the tablet have been reported to show significant cytotoxic potential. Thus In vitro cytotoxicity studies of the tablet powder and the phytosomal formulation is carried out on MCF-7 (Human breast adenocarcinoma cell lines) and MCF-10A (human breast epithelial cell lines). The tablet powder showed lesser IC50 values and greater cytotoxic potential compared to the phytosomal formulation on MCF-7 cell lines. Tablet powder showed lesser cytotoxicity on MCF-10A cell lines, whereas the phytosomes showed no cytotoxicity on normal breast epithelial cells by MTT assay.
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Pages:930-935
How to cite this article:
Jayni J Maru, Swati S Patil "Determination of cytotoxicity of a poly herbal ‘Meta-block 9‘tablet powder and its phytosomes on MCF-7 and MCF-10A cell lines, <em>in-vitro</em> ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 930-935
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