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VOL. 6, ISSUE 4 (2021)
Management of human cervical cancer using polyherbal phytosome: An in-vitro analysis
Authors
Swati S Patil, Bulti Debnath
Abstract
Herbal drugs are widely accepted in the field of medicine for the treatment of diseases. However, the procurement and processing of herbals are not only difficult but quite elaborate. From collection, preparation and evaluation of the extract, which has to comply with the standards results in receiving a small amount of plant actives though huge labour and solvents are involved. In addition, many phytoconstituents don’t attain the required dose in the targeted organ or tissue due to poor lipid solubility or larger molecular size resulting in reduced absorption and bioavailability thus requiring more concentration of drug in the dosage form. Therefore, novel drug delivery systems are employed to enhance their lipid solubility to diffuse through lipid- rich biological membranes. One of this technology is Phytosome, a new technique which incorporates extracts or phytoconstituents whose lipid solubility has to be enhanced to pass through biological layers with phospholipids leading to increased absorption and bioavailability so that its action is improved and therefore involving a lesser amount of extract concentrate. Cassia tora and Panchvalkal (an Ayurvedic preparation) are traditionally known for their medicinal properties which have been reviewed and examined by various studies. The modern medicine system though has made progress in treating different cancers, it is not free from side effects. The rationale of the research project was to combine them and formulate them into Phytosome formulation. The formulation thus made was optimization for maximum entrapment efficiency. Phytosome was produced using solvent injection method using phosphatidylcholine and cholesterol. Evaluation parameters like %Entrapment efficiency, particle size, Zeta, potential was performed. In-vitro diffusion study of phytosome exhibited 74.86% of cumulative drug release upto 24hrs. In-vitro cytotoxicity of phytosome complex on Human cervical cancer cell line (HeLa) was evaluated by using Cisplatin as standard drug. A novel drug delivery system that has been formulated thus improves the efficacy of the formulation which could be useful to treat any malignant transformations although sustaining properties of phytoconstituents.
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Pages:665-675
How to cite this article:
Swati S Patil, Bulti Debnath "Management of human cervical cancer using polyherbal phytosome: An <em>in-vitro</em> analysis ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 665-675
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