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VOL. 6, ISSUE 4 (2021)
Anti-asthmatic activities of an ethanol extract of Sarcostemma brevistigma in an Ovalbumin-induced model
Authors
S M Dhivya, K Kalaichelvi, S Sharmila, B Sajitha, S Mownika, E K Ramya
Abstract
Objectives: Sarcostemma brevistigma is used in old-stylemedicines to treat cough, asthma and insect bites; however, its therapeuticmechanism is not completely understood. Methods: To explain the anti-asthmatic effect of S.brevistigma, we investigated the therapeutic mechanism antiasthmatic properties in the ethanolic extract of S.brevistigma in an ovalbumin (OVA)-induced model. Results: In thisstudy, we showed that S.brevistigma significant decrease of body weight in mice sensitized to OVA and significant weight gain in the mice treated with ethanolic extract of test plant were noticed. PCV, HB and RBC were increased in all the test groups when compared with that of the OVA treated animals. These increases were statistically significant (p<0.05) in groups treated with 200 mg/kg and 400 mg/kg of plant extracts. A significant (p<0.001) decrease in WBC count and MCH was observed in same groups (200 mg/kg and 400mg/kg). There was no significant difference in the percentage of neutrophils (polymorphs), lymphocytes and monocytes count in all the test groups when compared with the control and treated groups and the histopathological variations in the lungs, whichreached normal levels in the OVA-challenged mice treated with S.brevistigma extract. Conclusion: These findings suggest that S.brevistigma could be a promising natural agent for treating bronchial asthma in humans.
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Pages:682-689
How to cite this article:
S M Dhivya, K Kalaichelvi, S Sharmila, B Sajitha, S Mownika, E K Ramya "Anti-asthmatic activities of an ethanol extract of <em>Sarcostemma brevistigma</em> in an Ovalbumin-induced model ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 682-689
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