The scientific name of noni fruit is Morinda citrifoila which belongs to the family Rubeaece. There are many pharmacological activities which are reported on Morinda citrifoila Linn fruit among these this review mainly focused on neuropharmacological actions of Morinda citrifoila Linn fruit. Anti-depression, Anti-anxiety, are the neuropharmacological activities reported on Morinda citrifoila Linn fruit by using in vivo, invitro models. Scopoletin, rutin, Eugenol, Hydroxy- chavicol, Quercetin, phenylpropanoid, are derivatives some of the Active principal compounds in which produce neuropharmacological actions and their quantification techniques mentioned in this review.