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VOL. 6, ISSUE 4 (2021)
Ameliorative effect of glycyrrhetinic acid in fatty acid induced steatosis of HepG2 cells
Authors
K Buvanesvaragurunathan, Soosaimanickam Maria Packiam, V Porchezhiyan, S Nagul Kumar, P Pandi Kumar
Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the important lifestyle disorders found across the globe and its prevalence is growing rapidly. There is no Food and Drug Administration (FDA) approved remedy for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and there is growing interest on the botanicals. This study aims to explore the anti-NAFLD effect of glycyrrhetinic acid in fatty acid induced steatosis of HepG2 cells. Glycyrrhetinic acid was isolated from the stems of Glycyrrhiza glabra L., and its structure was confirmed using spectroscopic studies. The anti-NAFLD effect of glycyrrhetinic acid was evaluated in fatty acid induced steatotic HepG2 cells. The Nuclear Magnetic Resonance (NMR) assignments of glycyrrhetinic acid were in agreement with previously published literature. The MTT assay showed that the compound did not possess any toxicity upto 100 µM. The treatment with glycyrrhetinic acid significantly lowered intracellular lipid accumulation and the leakage of transaminases from HepG2 cells. The efficacy of glycyrrhetinic acid was comparable with that of fenofibrate, the positive control drug. Further detailed investigations on this compound might yield some useful clues for the better management of NAFLD.
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Pages:676-681
How to cite this article:
K Buvanesvaragurunathan, Soosaimanickam Maria Packiam, V Porchezhiyan, S Nagul Kumar, P Pandi Kumar "Ameliorative effect of glycyrrhetinic acid in fatty acid induced steatosis of HepG2 cells ". International Journal of Botany Studies, Vol 6, Issue 4, 2021, Pages 676-681
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