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VOL. 6, ISSUE 5 (2021)
Exploration of the anti-inflammatory potential of polar extract of Alhagi pseudalhagi through docking studies
Authors
Garima Verma, Sushil Kumar, Amit Kumar
Abstract
Pharmacologically active molecules exhibit therapeutic anti-inflammatory effects due to cyclooxygenase-2 inhibition whereas cyclooxygenase-1 inhibition is the cause of unpleasant side effects. More selective cyclooxygenase-2 inhibitors have lesser side effects. Molecular docking is a bioinformatics modelling that involves an interaction between two molecules to create a stable adduct. The 3 dimensional structure of every complex depends on the ligand and target binding properties. Molecular docking generates several possible adduct structures, which are identified using the software scoring function and categorized. Plants of the Alhagi family have been commonly used for cure of a range of diseases including gastroenteritis, headaches, toothache, diarrhoea, rheumatoid arthritis and liver disease. In the current study, we explored the phytochemicals present in polar extract of Alhagi pseudalhagi: Kaempferol, rhamnetin, ombuine, isorhamnetin, tamarixetin, rutin, isoquercitrin, 1-O-β-methyl-glucoside, isoswertianolin, isorhamnetin-3-O-β-D-rutinoside, stigmasterol and tyramine were screened against Cyclooxygenase- 2 receptor (5KIR) using Autodock and Discovery studio. The docked phytochemicals exhibited significant binding with the cyclooxygenase- 2 receptor (5KIR) and paved the path for the development of polar extracts of Alhagi pseudalhagi as anti-inflammatory agent.
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Pages:1009-1014
How to cite this article:
Garima Verma, Sushil Kumar, Amit Kumar "Exploration of the anti-inflammatory potential of polar extract of <em>Alhagi pseudalhagi</em> through docking studies ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 1009-1014
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