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VOL. 6, ISSUE 5 (2021)
A comparative study between hepatoprotective and antioxidant activity by using leaf extract of Momordica dioica roxb
Authors
V Nandhinipriya, M Kumar, S Alexander, S Sangeetha
Abstract
In this study, the ethanol extract and the water extract of Momordica charantia had hepatoprotective activity. The effects of the leaves on carbon tetrachloride (CCl4) -induced liver injury in rats were evaluated. The extract was administered orally once a day at a dose of 200 mg/kg. Serum glutamate oxaloacetate aminotransferase (AST) significantly increased, serum glutamate pyruvate aminotransferase (ALT), serum alkaline phosphatase (SALP) and total bilirubin Serum enzyme levels increased significantly by extract Return to normalization. Silymarin was used as standard reference material and showed significant hepatoprotective activity against carbon tetrachloride-induced contact toxicity in rats. The biochemical observation was supplemented by histopathological examination of liver slices in rats. The results of this study clearly indicate bitter gourd Roxb. The leaves have a strong hepatoprotective effect on the liver damage caused by carbon tetrachloride in rats. The results prove that ethanol extract is a more effective hepatoprotective agent. At the same time, the antioxidant and free radical scavenging activities in the body were also selected, which were positive for ethanol and water extracts. This study shows that the possible mechanism of this activity may be due to the antioxidant and free radical scavenging activities produced by the presence of flavonoids in the extract.
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Pages:439-442
How to cite this article:
V Nandhinipriya, M Kumar, S Alexander, S Sangeetha "A comparative study between hepatoprotective and antioxidant activity by using leaf extract of <em>Momordica dioica</em> <em>roxb</em> ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 439-442
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